AFEW International and the members of AFEW Partnership develop informational materials, outreach programmes and peer training initiatives especially for young people living in high-risk circumstances. Activities for young people who use drugs and young offenders focus on information and education on healthy lifestyles, including information on HIV and drugs. 

Access to health services for young people who use drugs is hampered due to laws and regulations. With the help of the ombudsman in e.g., Ukraine AFEW-Ukraine addresses this access to services with policy makers and politicians.